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the STEP-1 trial reported approximately 14.9 percent on semaglutide over 68 weeks

These symptoms typically resolve within 24 hours.* Not for Everyone: This therapy is not recommended for individuals allergic to cobalamin (B12), those with liver disease, or those currently taking medications that interact with methyl donors

Additionally, individuals with active cancer are generally advised against NAD+ therapy due to theoretical risks of fueling cancer cell metabolism