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PROTAC degraders 245 and 246 selectively target HMGCR, a key enzyme in cholesterol biosynthesis, achieving efficient degradation in preclinical models

Key markers include HbA1c, lipid panels, inflammatory markers (CRP, IL-6), and body composition analysis

While that's a good thing, a recent study questions whether this reduces the risk of cardiovascular disease the main target of treatment

PMID 25033061

These distinctions motivate different endpoints (e.g., strain persistence vs

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