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Nausea, diarrhea and vomiting were most common, and about one in five patients reported mild dysesthesia

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The primary mechanism involves binding to GLP-1 receptors located throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

J Biol Chem 261: 11880-11889, 1986

Other medications in development might eventually match or beat retatrutide

For example, Kourtney Kardashians Lemme brand just launched Lemme GLP-1 Daily, touted on Instagram as 'a breakthrough innovation in metabolic health, formulated to naturally boost your bodys GLP-1 production, reduce appetite, and promote healthy weight loss.' US brands Supergut and Pendulum sell a Gut Healthy GLP-1 Booster and a GLP-1 Probiotic, respectively