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Assumptions and Methodology 12.2

Per IKS Health coding guidance: when a patient uses BOTH insulin AND oral agents, assign only Z79.4 (insulin takes precedence)

Over 80% of participants on the 12mg dose lost at least 15% of their body weight over 48 weeks

It should also be considered in patients whose obesity is due to snacking

Some patients mistakenly believe an early injection will 'boost' their weight loss, but consistencynot frequencydrives semaglutide success

Current FDA labeling for semaglutide products highlights this pathway: stomach and bowel side effects can lead to volume depletion, and acute kidney injury has occurred, including in postmarketing reports