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23 February 2026

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GGCT channels Gln flux for GSH synthesis and Glc anaplerosis into the TCA cycle ROS act as signaling molecules that regulate mitochondrial function, with mitochondrial morphology intrinsically linked to core processes, including the TCA cycle and oxidative phosphorylation

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If methylation is impaired, less homocysteine enters transsulfuration which reduces cysteine production