Isatuximab binds to the CD38 epitope via its gamma heavy chains, inducing cell death through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and apoptosis 146,147
glutathione helps manage this by protecting cells from damage
Its recommended to seek medical advice if experiencing the following or if these issues persist or worsen: Mild diarrhea Redness and pain at the injection site Swelling sensation in the body Temporary itching of the skin There may also be a risk of: Anaphylaxis (body goes into shock) Congestive heart failure Peripheral vascular thrombosis (involves blood clots) Polycythemia vera (a type of blood cancer) Pulmonary edema (too much fluid in the lungs) If you begin experiencing difficulty breathing, swelling, and hives, patients must seek emergency medical help
In a prospective open-label study, testing cabergoline at a dose of 1 mg/week, adjusted up to a maximal dose of 7 mg/week, showed a significant reduction of fasting serum glucose and insulin levels in CD patients responding to therapy (79)
Check for Patient Assistance Programs Many pharmaceutical companies offer patient assistance programs to help those who qualify reduce medication costs
The Mounjaro patient leaflet warns that nausea, vomiting and diarrhoea can cause fluid loss or dehydration, which may affect kidney function, and advises avoiding dehydration by drinking plenty of fluids
