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The hormone has become more well-known as GLP-1 agonist and GLP1-GIP receptor medications, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), have become prescribed more often

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The suspected mechanism is glucagon activity: the glucagon receptor is expressed in certain tissues of the peripheral nervous system, and its chronic activation appears to alter neurosensory signaling in some subjects

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