Eli Lilly sponsored SURMOUNT-5, (NCT05822830), a Phase IIIb, open label, multi-centre, randomised clinical trial to compare the efficacy and safety of tirzepatide (Zepbound) versus semaglutide (Wegovy) in overweight or obese adults and at least one additional named weight-related comorbidity that was not T2D 24
Side effects are rare but possiblealways consult a medical provider before starting
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They're derived from research investigating growth hormone secretagogue potency curves and receptor saturation thresholds
The FDA has approved more than 100 peptide-based drugs over the decades, including GLP-1 medications like semaglutide, which millions of people now take for weight loss