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In erythroleukemia K562 cells, in addition to the above identified NRF2 binding ARE motif, there is also a strong association of active histone codes (such as H3K4Me3, H3K9Ac, H3K27Ac, H3K79Me2) upstream of the transcription start site (Supplementary Fig

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The primary mechanism underlying ferroptosis is the accumulation of iron and lipid peroxidation, leading to a perturbation of oxidative homeostasis within the cellular microenvironment [220]

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10.1016/j.joim.2023.03.001 39 RendlM.PolakL.FuchsE

Vitamin C can donate an electron to the used-up glutathione, essentially "recharging" it so it can go back to work