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Participants with known cirrhosis, Stage 4 fibrosis on biopsy, or other severe chronic illness were also excluded

FQ was responsible for the planning of the overall experimental scheme and participated in the discussion, revision, completion of the final manuscript, and most of the experiments in this study

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The improvement in pharmacokinetics helped prevent the negative gastrointestinal side effects typical of GLP- 1-based selective agonists by reducing maximum drug exposure and reducing reliance on GLP- 1-mediated pharmacology