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Patients with a history of medullary thyroid carcinoma, personal or family history of multiple endocrine neoplasia type 2 (MEN2), or severe diabetic retinopathy should not use semaglutide

In the SUSTAIN 6 trial, there was no difference in hospitalization for angina or heart failure between semaglutide and placebo [12], and this result was independent of baseline CV risk profile (Fig

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Thus, to definitively determine if late-life pharmacologic modulation of IGF-1R signaling could improve survival, we performed a longevity study in female mice with lifelong i.p

Half were randomly assigned to take oral semaglutide, while the other half got a placebo