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[DOI] [PubMed] [Google Scholar] 246.Yuksel H., Sogut A., Yilmaz O., Onur E., Dinc G

Honda S, Farboud B, Hjelmeland LM, Handa JT

Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by berberine

May be associated with periductular fibrosis and periductular cell infiltration

However, free iron in mitochondria and the cytoplasm can generate highly oxidative HO, which damages polyunsaturated fatty acids (PUFAs) in the phospholipid bilayer, leading to mitochondrial outer membrane permeabilization (MOMP), ultimately abrogating DNA stability and inducing cell death

Lastly, Brachyury expression - often considered a NC marker and required for the differentiation of mesoderm into notochord [3] - was not detected in the human adult NP, which may argue against the hypothesis that both NC and CLCs are derived from the notochord [73]