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Some patients simply dont respond to therapy treatments, so they have to rely on drug-based pain management, including the side effects and dependencies that can arise

Strowski, M

The majority of what is known comes from controlled laboratory environments where variables such as species, dosage, timing, delivery route, and injury model differ significantly from one study to another

tsDMARDs also have special targets, for example, janus kinases (JAK) is the special target of tofacitinib, baricitinib, filgotinib, upadacitinib, and decernotinib (11)

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