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Chronic stress elevates cortisol, increases inflammation, disrupts sleep, triggers migraines, and undermines the metabolic benefits of tirzepatide

A major clinical trial called the SELECT trial, published in the New England Journal of Medicine, followed over 17,000 people who were overweight or obese and had existing heart disease

doi: 10.1056/NEJMoa1509225 251 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

Data availability All data used for this paper are publicly available and are provided in the main text and Supplementary Information

[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

Central Nervous System Effects : These medications interact with GLP-1 receptors in the hypothalamus and other brain regions that regulate appetite and energy homeostasis