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These include risks related to pancreatitis, gallbladder problems, low blood sugar when combined with certain diabetes medications, kidney problems related to dehydration, and a boxed warning about thyroid C-cell tumors based on animal studies
Although further dose-optimization studies are warranted to maximize the antiviral effect in the lower respiratory tract, phenformin showed antiviral activity in the upper respiratory tract, the main anatomic site for viral entry and spread
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