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The review is the first to compare efficacy of the three FDA-approved GLP-1 medications in nondiabetic patients using the drugs for weight loss

doi: 10.1038/nature12978 239 KimS-YNohY-WKangTHKimJ-EKimSUmSHet al

However, while we and others previously showed that GIPR agonism remains fully efficacious to decrease body weight and food intake in mice deficient for Glp-1r 15,18 , here we found that loss of Glp-1r renders mice resistant to weight loss and inhibition of food intake by GIPR antagonism