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In summary, the combination of sertraline and chloroquine targets different aspects of metabolic rewiring in GBM cells, i.e., nucleotide synthesis, redox homeostasis, and mitochondrial function, causing severe impairment of their proliferation and survival capabilities
Though it has multisystem involvement, it is the cardiovascular manifestations that are most prominent
thus, appropriate tests need to be carried out to rule out this condition if suspected (11)
As men have higher metabolic rates and muscle mass, they may experience rapid weight loss with regular exercise and dieting