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Studies in rodents have shown that GLP-1 receptor agonists, including semaglutide, cause dose-dependent and treatment-duration-dependent thyroid C-cell tumors

Larger doses of vitamin B12 can cause other more serious side effects including: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet Our doses are preservative free and extremely small, and therefore rarely cause a negative reaction

So, Bertholet et al

Night dosing, by contrast, introduces the peptide after NNMT has already processed the day's nicotinamide load

Simultaneously, it suppresses the release of glucagon, a hormone that raises blood sugar

Current research suggests that continued use is necessary to maintain weight loss