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Sadowski A, et al

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When you ingest L-citrulline supplements or foods containing L-citrulline, the kidneys transform it into L-arginine, another nonessential amino acid known for increasing nitric oxide production

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This leads to neuroinflammation, vascular occlusion, mitochondrial dysfunction, and the aggregation of pathognomonic proteins, which, in turn, trigger neurodegeneration in the cerebral cortex for AD and the substantia nigra for PD (illustrated in Fig