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These findings suggest that an anti-inflammatory, low-FODMAP diet may complement pharmacological treatment in alleviating FM symptoms [87]

By targeting key molecular pathways such as Wnt/-catenin, SMAD, PI3K/AKT, and MAPK/ERK, these therapies can modulate gene expression, cell signaling, and protein synthesis to optimize healing outcomes

Transdermal, implant, or injectable forms of HRT bypass this risk entirely

Sleeve gastrectomy removes about 80% of the stomach, leaving a narrow tube

This remains an area of active research rather than established clinical practice, and until adequately powered, randomised controlled trials assess the safety and efficacy of this specific combination, clinicians and patients should approach any claims about its benefits with appropriate scepticism