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Sympathetic activation was evident, with higher plasma norepinephrine levels and increased FosB expressiona marker of sustained neuronal excitationin the parvocellular paraventricular nucleus and the rostral ventrolateral medulla

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Retatrutide is showing extraordinary promise in clinical trials for severe obesity, but it is still an investigational medication undergoing Phase 3 evaluation because long-term safety, optimal dosing, side effects, and real-world outcomes still need rigorous study before FDA approval