In a rat model of MCAO-induced stroke, neurogenesis was increased by semaglutide treatment, as evidenced by significantly increased levels of neurogenesis-specific biomarkers including nestin (intermediate filament protein that is a known marker of neuronal progenitor cells), doublecortin (microtubule-associated protein considered to be a reliable marker of neurogenesis), stromal cell-derived factor-1 (SDF-1) (chemokine promoting endogenous regeneration in the ischemic brain), and its receptor CXCR4
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Studies found that intrathecal injection of GLP-1RAs effectively reduced formalin-induced peripheral nerve injury, as well as cancer- and diabetes-induced pain without causing serious adverse reactions
PubMed record Al-dulaimi S, et al
Maibach HI, Kligman AM
