glp-1 based therapeutics summit GLP-1-Based | Conference Day Two GLP1 Receptor Agonists—Effects beyond Obesity

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Prescription GLP-1 medications work by amplifying and extending this signal meaningfully reducing hunger, controlling cravings, and improving metabolic function in ways that diet and exercise alone cannot replicate

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10.1016/j.mrfmmm.2011.04.003 11 AunanJ

Our functional and structural data, along with molecular dynamics (MD) simulations, suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy