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This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group

Michael Zezas: Yeah, it's really hard to know, and I think the tension you and I talked about earlier, Stephen, about whether countries will be willing to make the trade off for access to superior AI models versus open and free models that might be inferior, that'll tell us if this is a viable strategy or not

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American Journal of Epidemiology, 160 (8), 784796