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Alternatively, researchers may opt to administer an alternative protocol, involving half the total epithalon dosage, referred to in the literature as the Ukrainian Protocol [26]: Total Dosage: 50mg epithalon Frequency: Administer 1 subcutaneous injection of 10mg epithalon on days 1, 5, 9, 13, and 17 of the study period

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(3) Oxidative stress reinforced the nuclear p53progerin interaction to accelerate hepatocyte premature senescence