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it's a scientifically recognized bidirectional communication pathway between your gastrointestinal tract and your skin

10.1001/archderm.1958.01560020074009 40 CanningP.SorrellF

Compound Information Primary Use: Skin glow, cosmetic recovery, and tissue support

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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Combined use should always follow clinical assessment and should not replace investigation of underlying causes