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At the same time, there is abnormal activity of osteoclasts, enhanced bone resorption, slow loss of bone mass, accompanied by thinning and fracture of bone trabeculae and thinning of cortical bone

Gently swirl or invert to dissolve do not vortex or shake vigorously, as this can disrupt the disulfide bond and active loop conformation

Seek immediate help for signs of allergic reaction or if you have red flag symptoms, are pregnant, immunosuppressed, or elderly

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Injection of one or two doses of corticosteroids with an interval of 4-6 months can reduce pain and inflammation

Thus, the reduced expression of esr1 in our retinal homogenates may reflect overall reduced levels of ER in zebrafish retina, though we were able to measure expression of esr1 in our homogenates