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Wacal C, Musinguzi SP, Ewaju E, Atibo C, Alowo D, Alipa J, et al

We generally see it more in middle aged patients

Treatment coordinately improved mitochondrial abundance through isoform 1 and muscle mass through isoform 4 of the myocyte-specific PGC1, which was required for the treatment-driven increase in carbon shuttling from glucose oxidation to amino acid biogenesis

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doi: 10.1186/s12864-018-4718-6 22 GramaticaA.SchwarzerR.BrantleyW.Varco-MerthB.SperberH

Current Zepbound labeling includes specific contraception precautions around treatment initiation and dose escalation