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The irregularity in blood flow can lead to clot formation, particularly in a small, pouch-like area of the heart called the left atrial appendage

The similarity between the unadjusted and adjusted estimates suggested that the single interim analysis had little influence on the final effect size and the reported treatment effect was unlikely influenced by type I error associated with the group sequential design

In a randomised clinical trial with 48 participants, low-dose semaglutide reduced the amount of alcohol consumed by patients with alcohol use disorder, and reduced cravings for alcohol and cigarettes, over 9 weeks

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Whats the best evidence-based way to describe that tradeoff

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