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De Block CEM, Dirinck E, Verhaegen A, Van Gaal LF

Since the use of animal insulin for the treatment of diabetes in 1922, about nine major classes of drugs for the treatment of diabetes have been discovered and developed worldwide, including sulfonylureas, biguanides, -glucosidase inhibitors, insulins, thiazolidinediones (TZDs), meglitinides, GLP-1RAs, DPP-4 inhibitors, and SGLT-2 inhibitors

Roger H

Conducted in artificial cell lines, the findings did not address the key question as to whether the truncated form of GLP-1 located in the gut activated the pancreas to release insulin in the way incretin was presumed to work

10.1038/s41580-020-00317-7 16 CantiniG.MannucciE.LuconiM

The SELECT trial was the first large, randomized study to show that a drug used for obesity could reduce cardiovascular disease, says Isaacs