Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons
1,4,21,22 However, it is worth mentioning that some studies reported pain at the site of injection and knee pain which could have been induced by an overload of volume due to lack of absorption by the damaged meniscus
Similarly, in periodontal tissues, it induces ferroptosis in fibroblasts by activating the HIF-1/p38 Mitogen-Activated Protein Kinase pathway and enhancing HIF-1/Cyclin-Dependent Kinase 9/ Bromodomain-Containing Protein 4 interactions, leading to NCOA4-mediated ferritinophagy (Zhao et al., 2020)
The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content
Sharma V, Sethuraman G, Kumar B
Camele, E