The significant decrease in arachidonic acid, octadecadienoic acid, DHA, glycerophosphate, and 3-hydroxybutyrate in cardiomyocytes indicated that L-carnitine combined with trimetazidine affected the metabolism process of lipids and promoted oxidation and metabolism of fatty acids, as well as the production of ATP, and reduced the accumulation of fatty acids and the use of 3-hydroxybutyric acid
Recent experimental work consistent with this framework includes studies of CYP2E1-mediated oxidative stress in alcohol-related liver injury and of stage-dependent oxidative responses in repeated toxic liver injury (Jung et al., 2024
Meanwhile, translating other promising preclinical findings, such as those involving BPC-157, to clinical practice requires thorough investigation to ensure safety and efficacy
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Next, we characterized the difference at the single metabolite level between groups
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