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Gooderham 2013

Such modification alters the essential intramolecular and intermolecular interactions (van der Waals forces, hydrogen bonding, and - stacking) between proteins and nucleic acids, ultimately affecting the structure and function of target proteins [2,3]

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Although the cyclic form is more robust, mechanical stress can disrupt the conformation

Gut health and sleep: an emerging connection Your gut microbiome plays a larger role in sleep than many people realise