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in addition, the regulatory mechanism of d-carnitine on nutritional metabolism in fish was not yet known now ( Reference Santulli and DAmelio 23 , Reference Santulli and DAmello 28 )

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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included