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Semaglutide works primarily by enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

Future Research Directions Novel Therapeutic Targets Emerging therapies targeting endothelial dysfunction, blood-brain barrier repair, inflammation, oxidative stress, and white matter regeneration are under investigation

Twice-weekly injections might theoretically maintain more consistent GLP-1 receptor activation throughout the week, potentially reducing hunger variability