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These include the outer surface of the upper arm, the upper area of the front of the thigh, the abdomen (two inches from the belly button), and the buttocks (MedlinePlus, 2021)

Splitting into twice-daily injections is reasonable at higher daily totals (e.g., 250 mcg AM + 250 mcg PM at a 500 mcg/day total)

However, in some cases, your doctor may recommend a B12 shot or injection

Copper-catalyzed oxidation of methionine produces methionine sulfoxide (reversible) and potentially methionine sulfone (irreversible)