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It is widely used clinically to treat drug-induced liver injury (DILI) by protecting hepatocyte membranes, exerting anti-inflammatory and immunomodulatory effects, and demonstrating corticosteroid-like actions that promote hepatocyte repair, enhance hepatic protein synthesis, prevent fibrosis, and strengthen anti-allergic and detoxification capacities

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 80% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof