Practice Bulletin, 196, 1-18
It is naturally produced in the liver and plays a vital role in: Detoxification : Helping the liver eliminate harmful toxins
It showed that different ways of giving vitamin B12, like shots, pills, or under the tongue, work well
Amino Acids Regulating Skeletal Muscle Metabolism: Mechanisms of Action, Physical Training Dosage Recommendations and Adverse Effects. Nutrition & Metabolism , vol
Nocturnal enuresis (a pediatric indication - attributed to its antimuscarinic side effects) Contraindications: Drugs that inhibit monoamine oxidase (MAOI's) taken w/in 14 days, acute recovery period after a myocardial infarction, or history of drug hypersensitivity Side Effects: drowsiness dry mouth & eyes constipation orthotstatic hypotension mild tremor sweating agitation nausea tinnitus Overdose & Treatment: See Amitriptyline
This led to FDA black box warnings requiring screening for glucose intolerance before starting treatment and periodic monitoring during treatment, with recommendations against use in patients with poorly controlled diabetes
