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DIOs, by regulating the conversion of thyroxine (T4) to triiodothyronine (T3) and reversing triiodothyronine (rT3) and thyroidonamines, control thyroid hormone turnover [3]

Together, these observations demonstrate marked variability in the ability of short-term metformin to lower rates of gluconeogenesis under basal or clamp conditions in youth and adults with modest hyperglycaemia

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