They also make your body more resistant to insulin and can increase inflammation, both of which get in the way of how well GLP-1 works
GLP-1 receptor agonists are prescription medications that mimic the glucagon-like peptide-1 hormone, aiding blood sugar regulation and suppressing appetite
If the FDA will require outcomes trials for future approvals in obesity, this will add considerable time and cost to drug development
216,217 Exendin-4 was also demonstrated to increase lysosomal function in another study, whereby autophagosome clearance in a rat model of tacrolimus-induced diabetes was increased, promoting cell survival given that autophagosome accumulation causes intracellular damage
Clinical trials tested weekly doses up to 12 mg for 48 weeks with manageable side effect profiles
A lot of the drugs [may not work the same way for every patient]