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Zhang and others discovered that Polygonum sibiricum polysaccharides (PSP) were capable of elevating serum levels of 5-HT and NE, reducing pro-inflammatory cytokine levels in the hippocampus, as well as inhibiting the PI3K/AKT/TLR4/NF-B and ERK/CREB/BDNF pathways in mice with depression induced by CUMS (Zhang et al., 2023)

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The strain is also reported to reduce the oxidative stress markers in blood and urine in humans [102]

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Lethal cardiomyopathy in mice lacking transferrin receptor in the heart