In contrast, drugs modeled after gastrointestinal hormones, such as glucagon-like peptide-1 (GLP-1), have been shown to exhibit fewer side effects while demonstrating high efficacy in obesity treatment
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Together, Marks argues, this work 'established beyond any doubt, the hormonal nature of glucagon even though no endocrinological disease had yet been identified as a result of its over or under secretion' (Marks 2018)