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10.1016/j.numecd.2005.05.003 Nutr Metab Cardiovasc Dis

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Prostaglandin E2 (PGE2) along with HER2 and growth factors enhance aromatase activity via post-transcriptional mechanisms in BrCa cells mediated by the IGF-1/IGF-1R axis through both AKT and MAPK pathways

Therefore, GPX4 activation could be used as a new anti-inflammatory or cytoprotective therapy (Fig