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Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Nature 469:221225 Funding The authors declare that no funds or grants were received during the preparation of this manuscript

FDA-approved for type 2 diabetes and for reducing the risk of major adverse cardiovascular events in certain adults with type 2 diabetes and established cardiovascular disease

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Subsequent biochemical and cytochemical studies demonstrated that HGF nitration is maximal in a physiological pH range at Y198 and Y250, characterized by their respective locations at the c-met binding sites of the K1 and K2 domains of the HGF -chain