what is the average weight loss per week on tirzepatide and Semaglutide key differences, results (2026) Average Weight Loss Per Week

23 The results clearly favored Zepbound

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Based on the promising preclinical data, Bunce conducted a small, double-blind, placebo-controlled trial funded by the National Institute on Drug Abuse and Novo Nordisk, the company that makes Ozempic and Wegovy

FDA drug labeling, Mounjaro (tirzepatide) prescribing information California Medi-Cal excluded weight-loss GLP-1s (Wegovy, Zepbound, Saxenda) effective January 1, 2026 Mounjaro's diabetes coverage is unaffected

Novo CagriSema (cagrilintide + semaglutide) In REDEFINE-4 (84 weeks), CagriSema 2.4/2.4 mg delivered: 23.0% weight loss (efficacy estimand) 20.2% (treatment-regimen estimand) Missed non-inferiority vs tirzepatide Takeaway: Clinically strong, but not a category reset

PlexusDx compounded tirzepatide injection is prepared by licensed 503A compounding pharmacies and is $289/mo month-to-month, or from $249/mo on the 6-month plan across all commitment tiers