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others have minimal or none

Animal reproduction studies have shown fetal skeletal and cardiovascular effects at high doses, though direct human pregnancy data remains extremely limited because pregnant individuals are excluded from clinical trials

For example, scientists are developing GLP-1 drugs that require only monthly injections

Weight loss plateaus on GLP-1 therapy are normal and typically last one to three weeks

GLP-1 medications carry important warnings and contraindications, including a boxed warning for thyroid C-cell tumors in rodents (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)

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