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High-dose oral B12 utilizes passive diffusion (about 12% of dose) even without intrinsic factor, making it effective for many malabsorption conditions

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Once injected, it helps utilize fats and carbohydrates for energy

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The trial therefore provides no conclusive evidence that early adjunct therapy with amantadine provides true protective effects against the development of LIDs as opposed to its well-known symptomatic efficacy [135]

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