Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor
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The IF staining and Western blot analyses for -H2AX, a marker for DNA double-strand damage, and phosphorylated nucleophosmin 1 (pNPM1) required for DNA damage repair were performed in RSL3-treated K1 cells
Relevant clinical trials should assess outcomes such as sleep-onset latency, total sleep time, wakefulness after sleep onset, sleep efficiency, daytime functioning and patient-reported symptoms