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Monolayers of immortalized mouse brain endothelial cells (bEnd.3) were treated with recombinant TGF 1 (rTGF 1) and permeability to fluorescein isothiocyanate-dextran (FITC-dextran), MMP9 and claudin-5 expression was assessed

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In the UK, commonly prescribed GLP-1 receptor agonists include: Semaglutide (Ozempic for type 2 diabetes

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Mitochondria also host antioxidant enzymes such as superoxide dismutase (SOD) and catalase as the first line of defense against ROS by converting superoxide to H 2 O 2 and subsequently to water