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Converging evidence suggests that reductions in cerebral blood flow (CBF) and cerebrovascular dysfunction may precede structural and functional deficits associated with neurodegeneration, representing one of the earliest indicators of ADRD risk (Jack et al., 2010), and therefore, cerebrovascular dysfunction may serve as an ideal early-stage biomarker that is receptive to aerobic exercise interventions (Kleinloog et al., 2019

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Long-term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials